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KMID : 1007520120210020612
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Food Science and Biotechnology
2012 Volume.21 No. 2 p.612 ~ p.617
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Isolation and Identification of Flavonoids from Gujeolcho (Chrysanthemum zawadskii var. latilobum) as Inhibitor of Histamine Release
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Shim Sun-Yup
Kang Hye-Sook
Sun Hyeon-Jin
Lee Young-Ju
Park Jeong-Ro
Chun Soon-Sil
Song Young-Hwan
Byun Dae-Seok
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Abstract
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In an ongoing search of compounds from natural sources that exhibit anti-allergic properties, 3 flavonoids were isolated from the ethyl acetatefraction of methanol extracts of gujeolcho (Chrysanthemum zawadskii var. latilobum), with guided histamine release inhibitory effects. The isolated compounds were identified as eriodictyol- 7-O-β-D-glucuronide, 5,7-dihydroxy-4-chromene, and 6- methoxyluteolin based on spectroscopic evidences including NMR and MS spectra. These results suggest that gujeolcho extracts and 3 compounds would be candidates as therapeutic or preventive agents for allergic reaction.
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KEYWORD
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Chrysanthemum zawadskii var. latilobum, histamine, flavonoid
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